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Serum resistin concentration and insulin resistance in obese children / 中华儿科杂志
Chinese Journal of Pediatrics ; (12): 114-117, 2006.
Artigo em Chinês | WPRIM | ID: wpr-355462
ABSTRACT
<p><b>OBJECTIVE</b>Obesity is an important risk factor of insulin resistance and type 2 diabetes. Adipocyte is a cell that can actively secrete a series of factors to regulate the pathway responsible for energy balance. Resistin is one of these factors. The purpose of this study was to investigate possible correlation between resistin and certain parameters, including body parameters and other parameters of glucose metabolism and roles of resistin in hyperinsulinemia or insulin resistance in obese children.</p><p><b>METHODS</b>The serum resistin concentration was measured in 34 obese children (18 boys, 16 girls; age 8.9-15.9 years) and 31 normal subjects (16 boys, 15 girls; age 7.8-14.5 years) by using ELISA. Anthropometric parameters, fasting glucose and insulin were measured in all subjects. Insulin resistance was assayed by homeostasis model assessment ratio (HOMA-R). Beta cell function was determined by using homeostasis model assessment beta cell (HOMA-beta). Correlation analysis was performed between resistin and other parameters.</p><p><b>RESULTS</b>(1) The serum resistin concentration (common logarithmic transformation) was 3.1 +/- 0.5 in obese subjects and 2.7 +/- 0.8 in normal subjects. (P < 0.05). (2) The serum resistin concentration was not significantly correlated with sex, age, systolic and diastolic blood pressures, but was positively correlated with BMI, percent body fat (BF%), waist-hip ratio (WHR) (r = 0.299, r = 0.304, r = 0.322, P < 0.01); and positively correlated with fasting glucose, insulin, HOMA-R (r = 0.299, r = 0.303, r = 0.324, P < 0.05), but not significantly correlated with HOMA-beta. (3) Multiple linear regression analysis showed that only HOMA-R was the factor that significantly influenced resistin, R(2) = 0.105, the standard partial coefficient was 0.279 (P < 0.01).</p><p><b>CONCLUSIONS</b>The serum resistin concentration in obese children were higher than that in normal children. The serum resistin concentration significantly correlated with the degree of obesity and the distribution of fat. Resistin is probably related to occurrence of hyperinsulinemia and/or insulin resistance in obese children.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Sangue / Glicemia / Resistência à Insulina / Ensaio de Imunoadsorção Enzimática / Biomarcadores / Índice de Massa Corporal / Estudos de Casos e Controles / Modelos Lineares / Jejum Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Criança / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pediatrics Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Sangue / Glicemia / Resistência à Insulina / Ensaio de Imunoadsorção Enzimática / Biomarcadores / Índice de Massa Corporal / Estudos de Casos e Controles / Modelos Lineares / Jejum Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Criança / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pediatrics Ano de publicação: 2006 Tipo de documento: Artigo