Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 807-811, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-355890
ABSTRACT
<p><b>OBJECTIVE</b>This prospective registered study was conducted to investigate the impact of statins (pravastatin, fluvastatin, atorvastatin) on clopidogrel platelet inhibition in patients with acute coronary syndrome (ACS) or stable angina.</p><p><b>METHODS</b>A total of 1015 consecutive patients with ACS or stable angina underwent coronary angiography/percutaneous coronary intervention (PCI) were allocated to pravastatin group (n = 228), fluvastatin group (n = 179), atorvastatin group (n = 481) or placebo control group (n = 127). Baseline characteristics, coronary angiography/PCI features and acute stent thrombosis, platelet aggregation induced by 2, 5, 10 and 20 micromol adenosine diphosphate (ADP) at 1 minute (ADP-1), 5 minutes (ADP-5) and maximal platelet aggregation (ADP-M) were compared among groups.</p><p><b>RESULTS</b>Baseline and procedural characteristics were comparable among the four groups. Acute stent thrombosis (pravastatin group 0.9%, fluvastatin group 1.1%, atorvastatin group 1.0% and control group 0.8%, all P > 0.05), ADP-1, ADP-5, and ADP-M (all P > 0.05) were also similar among groups. Multivariate liner and ordinal logistic analysis revealed that age (B = 0.21, P = 0.001), dose of clopidogrel (B = 7.30, P = 0.002) and use of low-molecular heparin (OR = 6.71, P = 0.01) were independent factors for platelet aggregation inhibition efficacy by clopidogrel.</p><p><b>CONCLUSION</b>Inhibition of platelet aggregation with clopidogrel was influenced by age, clopidogrel dose and low-molecular heparin but not by various statin treatments.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Contagem de Plaquetas
/
Testes de Função Plaquetária
/
Pirróis
/
Ticlopidina
/
Ácidos Graxos Monoinsaturados
/
Inibidores da Agregação Plaquetária
/
Difosfato de Adenosina
/
Agregação Plaquetária
/
Estudos Prospectivos
/
Pravastatina
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2008
Tipo de documento:
Artigo
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