Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats.</p><p><b>METHODS</b>The fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected.</p><p><b>RESULTS</b>Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01).</p><p><b>CONCLUSION</b>Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.</p>