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Polymorphism of HLA-B* 40 gene family in Chinese Han population / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 215-218, 2005.
Artigo em Chinês | WPRIM | ID: wpr-356590
ABSTRACT
To investigate the allele distribution of HLA-B* 40 gene family in Chinese Han population and to study its influence on the selection of clinical transplantation donor, the HLA-B genetypes of 381 individuals randomly selected from Chinese National Marrow Donor Project were identified by PCR-SSO, and then all the HLA-B* 40 positive samples from the above population and the B* 40 homozygote samples received from another 1 270 registered donors were analyzed by PCR-SBT and PCR-SSP at high resolution. The results showed that the population of 381 registered donors was examined at HLA-B locus by using Hardy-Weinberg equilibrium, the gene frequency of HLA-B* 40 was 0.1692. Four different HLA-B* 40 alleles (B* 4001, B* 4002, B* 4003, B* 4006) were identified, and the serological specificity was B60 and B61 respectively. The relative frequency of each allele was 0.1192 for B* 4001, 0.0154 for B* 4002, 0.0038 for B* 4003, 0.0308 for B* 4006. The distribution of B* 40 homozygote revealed a certain regularity at high-resolution, B* 40XX (B* 4001 group), at low-resolution; B* 4001 at high resolution; B* 40XX (B* 4002 group), at low-resolution; B* 4002 or B* 4006 or heterozygote of both at high-resolution. It is concluded that in Chinese Han population, predominant allele in HLA-B* 40 gene family is B* 4001, the high-resolution typing may be recommended to use for the selection of clinical transplantation donor.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Doadores de Sangue / Antígenos HLA-B / China / Reação em Cadeia da Polimerase / Povo Asiático / Alelos / Antígeno HLA-B40 / Frequência do Gene / Genética Limite: Humanos País/Região como assunto: Ásia Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Polimorfismo Genético / Doadores de Sangue / Antígenos HLA-B / China / Reação em Cadeia da Polimerase / Povo Asiático / Alelos / Antígeno HLA-B40 / Frequência do Gene / Genética Limite: Humanos País/Região como assunto: Ásia Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2005 Tipo de documento: Artigo