Changes of response patterns to excitatory stimuli of different intensities: a model-based study of cochlear nucleus neurons / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>The cochlear nucleus (CN) neurons show 3 principal response patterns to short tone bursts, namely the primary-like, chopper and onset response patterns. We previously established an excitatory model to simulate the response patterns of CN neurons to stimuli. In this study, we aimed to investigate the effects of excitatory intensity on the CN neuron response patterns and explore the role of inhibitory inputs under normal physiological conditions.</p><p><b>METHODS</b>Based on the platform of Matlab and the excitatory model derived from the integrate-and-fire model, we altered the intensity of excitatory inputs in dB range and obtained the histograms to analyze the changes in the response patterns of the neurons using OriginPro 7.5 data analysis software.</p><p><b>RESULTS</b>The original primary-like response pattern of the neurons did not vary significantly while the chopper and onset response patterns changed into primary-like responses with the increase of the excitatory input intensity. But this response pattern alteration as a result of excitatory input intensity changes was rarely observed under normal physiological conditions.</p><p><b>CONCLUSIONS</b>The CN neurons receive balanced excitatory and inhibitory inputs, which stabilize the neuronal membrane potential within a limited range. The balanced inhibitory inputs decide the response pattern of a given neuron.</p>