Osteogenesis of HA/TCP biphasic ceramics implanted into muscle: a long-term study / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 361-364, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-357027
ABSTRACT
New bone formation in long-term intramuscle implant of Ca-P biomaterial was investigated in this experiment. After implanting into dog dorsal muscle for 15 months, a thin fibrous membrane that wrapped HA/TCP implant was still observed obviously. Three types of tissues, i.e. mesenchymal tissue, bone and bone marrow, regularly distributed in different pores of implant. Nearly all the pores of implants were occupied by bone. Bone in the pores located in the central region of implant was matured lamellar bone characterized by obvious lacuna and rich bone marrow. However, bone in the peripheral pores was immature woven bone without bone marrow formation. Furthermore, mesenchymal tissues only exist in the peripheral pores and usually were connected with immature woven bone. It was demonstrated that porous HA/TCP has bone inductivity and it could induce new bone formation at non-osseous site. Well-regulated distribution of mesenchymal tissue, bone and bone marrow in the pores suggest bone morphogenesis in the implant must obey a specific space-time program.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Farmacologia
/
Materiais Biocompatíveis
/
Teste de Materiais
/
Cerâmica
/
Substitutos Ósseos
/
Implantes Experimentais
/
Hidroxiapatitas
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2002
Tipo de documento:
Artigo
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