Experimental research of PDE5 activity in corpora cavernosa of ganyu qizhi rat model / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVES</b>To study the PDE5 activity in corpora cavernosa of the Ganyu Qizhi model penis and the effect of the Chinese herbal medicine Shugan Liqi Huoxue (SLH) ointment on it.</p><p><b>METHODS</b>Non-injury stress stimulus method similar to human spirit stress was used to extablish the Ganyu Qizhi animal(rat) model, and the PDE5 activity in corpora cavernosa of the rat penis was measured by the method of immunohistochemistry and computer image analysis.</p><p><b>RESULTS</b>The PDE5 activity in corpora cavernosa of the high-dosage SLH group was significantly different from that of the model group (P < 0.01).</p><p><b>CONCLUSION</b>Ganyu Qizhi may increase the PDE5 activity in corpora cavernosa of the penis while SLH can reduce such activity.</p>