Advances in researches on lactate dehydrogenase-C4 isozyme / 中华男科学杂志
National Journal of Andrology
;
(12): 607-610, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-357125
ABSTRACT
Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Papio
/
Espermatozoides
/
Transcrição Gênica
/
Vacinas Anticoncepcionais
/
Alergia e Imunologia
/
Genética
/
Isoenzimas
/
L-Lactato Desidrogenase
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2003
Tipo de documento:
Artigo
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