Clinical significance of tumor budding detection in stage II colon cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 730-734, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-357153
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of tumor budding with recurrence and survival of patients with stage II colon cancer, in order to identify patients with high-risk recurrence who may benefit from adjuvant therapy.</p><p><b>METHODS</b>Clinical data of 112 stage II colon cancer patients in Guangzhou Red Cross Hospital between 1998 and 2007 were analyzed retrospectively. The degree of tumor budding was assessed by two observers and classified according to the number of tumor buds in the area with the greatest budding intensity on HE stain slides, as high-grade budding (≥10, n=30) and low-grade budding (≤9, n=82). Progression-free and cancer-specific survival were analyzed using the Kaplan-Meier method and Cox regression.</p><p><b>RESULTS</b>All the patients were followed up and the median follow-up was 78 months. The 5-year progression-free survival rates for patients with high-grade and low-grade budding were 65.3% and 90.7% respectively (P=0.008). The 5-year cancer-specific survival rates were 72.1% and 93.8% respectively (P=0.001). Cox regression analysis demonstrated tumor budding was an independent predictor of disease progression (RR=4.572, 95%CI2.218-11.746, P=0.002) and cancer-related death (RR=4.116, 95%CI1.657-10.384, P=0.012).</p><p><b>CONCLUSION</b>Tumor budding is a strong prognostic index for adverse outcome in stage II colon cancer patients,which may serve as a prognostic marker to identify patients with high risk of recurrence who may benefit from adjuvant therapy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Cirurgia Geral
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Seguimentos
/
Neoplasias do Colo
/
Recidiva Local de Neoplasia
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Estadiamento de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2013
Tipo de documento:
Artigo
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