Origin of Hematopoietic Stem Cells in Bone Marrow--Endothelial to Hematopoietic Transition (EHT)? / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 866-870, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-357256
ABSTRACT
In contrast to primitive hematopoiesis, during embryonic definitive hematopoiesis, it has been demonstrated that multilineage hematopoietic stem/progenitor cells (HSPCs) arise from hemogenic endothelium, and the endothelial to hematopoietic transition (EHT) exists within the yolk sac, placenta, AGM, mouse head vascular and extraembryonic vessels. However, whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, including fetal liver and bone marrow, remains largely unknown. Recently, more and more researches showed that hematopoiesis within bone marrow had a close relationship with vascular endothelium development, too. This review summarizes the mechanism of EHT during embryo development, and discuss whether EHT exists in adult hematopoiesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Placenta
/
Saco Vitelino
/
Medula Óssea
/
Células-Tronco Hematopoéticas
/
Endotélio Vascular
/
Diferenciação Celular
/
Células Endoteliais
/
Desenvolvimento Embrionário
/
Endotélio
/
Hemangioblastos
Limite:
Animais
/
Gravidez
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2015
Tipo de documento:
Artigo
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