Correlation of Epstein-Barr virus infection and childhood lymphoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 365-367, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-357421
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation of Epstein-Barr virus (EBV) infection and childhood lymphoma.</p><p><b>METHODS</b>Paraffin-embedded specimens of lymphoma collected between 1996 and 2005, including 36 Hodgkin lymphomas (HL) and 51 non-Hodgkin lymphomas (NHL), were included in this study. Paraffin-embedded specimens of reactive hyperplasia of lymph nodes (RL) collected during the same period were used as controls. Immunohistochemical (IHC) assay was used to detect EBV-LMP1 and in situ hybridization (ISH) to detect EBV-EBERs.</p><p><b>RESULTS</b>EBV was detected in 72.2% (26/36) of the Hodgkin lymphomas, 15.7% (8/51) of the non-Hodgkin lymphomas and 33.3% (15/45) of the reactive hyperplasia of lymph nodes. There was a significant difference among Hodgkin lymphoma, non-Hodgkin lymphoma and RL (P = 0. 000).</p><p><b>CONCLUSION</b>Childhood Hodgkin lymphoma is closely correlated with Epstein-Barr virus infection. However, the low rate of EBV infection detected in childhood non-Hodgkin lymphoma might be due to heterogeneous distribution of pathological types in this study.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Linfoma não Hodgkin
/
RNA Viral
/
Doença de Hodgkin
/
Proteínas da Matriz Viral
/
Herpesvirus Humano 4
/
Pseudolinfoma
/
Infecções por Vírus Epstein-Barr
/
Metabolismo
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2008
Tipo de documento:
Artigo
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