Research Progress of NOS3 Participation in Regulatory Mechanisms of Cardiovascular Diseases / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 188-192, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-357829
ABSTRACT
Cardiovascular disease has been a major threat to human's health and lives for many years. It is of great importance to explore the mechanisms and develop strategies to prevent the pathogenesis. Generally, cardiovascular disease is associated with endothelial dysfunction, which is closely related to the nitric oxide (NO)-mediated vasodilatation. The release of NO is regulated by NOS3 gene in mammals' vascular system. A great deal of evidences have shown that the polymorphism and epigenetic of NOS3 gene play vital roles in the pathological process of cardiovascular disease. To gain insights into the role of NOS3 in the cardiovascular diseases, we reviewed the molecular mechanisms underlying the development of cardiovascular diseases in this paper, including the uncoupling of NOS3 protein, epigenetic and polymorphism of NOS3 gene. The review can also offer possible strategies to prevent and treat cardiovascular diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Polimorfismo Genético
/
Vasodilatação
/
Doenças Cardiovasculares
/
Epigênese Genética
/
Óxido Nítrico Sintase Tipo III
/
Genética
/
Metabolismo
/
Óxido Nítrico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2016
Tipo de documento:
Artigo
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