Effects of Alopecia Areata Serum on Proliferation of Cultured Dermal Papilla Cells / 대한피부과학회지
Korean Journal of Dermatology
;
: 1032-1036, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-35785
ABSTRACT
BACKGROUND:
Dermal papilla cells, which are mesenchymal components of the hair bulb are considered to play an important role in the regulation of hair growth by production of diffusible factors that stimulate follicular epithelial cells. Degenerative changes in the dermal papilla cells in the involved scalp of alopecia areata cases indicate that these cells are one of the important targets in this disease.OBJECTIVE:
We investigated the effects of serum from alopecia areata patients on the proliferation of dermal papilla cells.METHOD:
Dermal papilla cells and fibroblasts from normal human scalp were cultured in DMEM media with 10% or 20% of normal and alopecia areata serum for 48hrs and 96hrs. Cell proliferation was measured by cell counts and [3H]-thymidine incorpoartion.RESULTS:
Both 10% and 20% alopecia areata serum had no significant effects on the proliferation of dermal papilla cells and fibroblasts after 48hrs and 96hrs.CONCLUSION:
These results suggest that there are no serum factors that inhibit the proliferation of dermal papilla cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Couro Cabeludo
/
Contagem de Células
/
Proliferação de Células
/
Células Epiteliais
/
Alopecia
/
Alopecia em Áreas
/
Fibroblastos
/
Cabelo
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1998
Tipo de documento:
Artigo
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