Effects of the Panax notoginseng saponins on the level of synaptophysin protein in brain in rat model with lesion of Meynert / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 913-915, 2005.
Article
em Zh
| WPRIM
| ID: wpr-358057
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effect of Panax notoginseng saponins (PNS) on the level of synaptophysin ptotein in brain in rat model with Alzheimer's disease (AD).</p><p><b>METHOD</b>The AD rat models were established by intra-peritoneal injection of D-galactose combined with excitatory neurotoxin ibotenic acid injection into bilateral nbM. The activity and content of synaptophysin protein in brain were determined by immunohistochemistry analysis.</p><p><b>RESULT</b>PNS could reduce the lesion of level of synaptophysin protein in brain, as compared with those of model group's rats.</p><p><b>CONCLUSION</b>PNS plays a protective role by reducing down of the level of synaptophysin protein in brain in lesion of AD animal model.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Plantas Medicinais
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Encéfalo
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Química
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Sinaptofisina
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Ratos Wistar
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Fármacos Neuroprotetores
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Núcleo Basal de Meynert
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Ginsenosídeos
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Article