Preparation of transfersomes of vincristine sulfate and study on its prcutaneous penetration / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 900-903, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-358061
ABSTRACT
<p><b>OBJECTIVE</b>To select the best preparation method of vincristine transfersomes (VCR-T) and predict its possibility of being a new formulation of VCR.</p><p><b>METHOD</b>Orthogonal design was used to optimize the preparation methods on the basis of single factor pretests; and the permeation tests in vitro were performed in modified Franz diffusion cells.</p><p><b>RESULT</b>The optimum formula was pH was equal to 7.3, the ratio of lecithin to sodium deoxycholate is 70/20, the weight of VCR is 10 mg, hydrating time is 30 minutes. The optimized solution was light yellow and transparent colloid solution. The VCR-T are spherical and smooth with average diameters of 94 nm and an encapsulation ratio of 90%. The test in vitro showed that VCR-T could permeat through mouse skin at zero rate with the cumulative penetrating quality amounting to 63.8%.</p><p><b>CONCLUSION</b>Transfersomes may become a promising carrier of VCR for clinic use.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Fosfatidilcolinas
/
Absorção Cutânea
/
Vincristina
/
Administração Cutânea
/
Portadores de Fármacos
/
Farmacocinética
/
Tecnologia Farmacêutica
/
Ácido Desoxicólico
/
Concentração de Íons de Hidrogênio
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Artigo
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