New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer / 国际口腔科学杂志·英文版
International Journal of Oral Science
; (4): 71-74, 2013.
Article
em En
| WPRIM
| ID: wpr-358192
Biblioteca responsável:
WPRO
ABSTRACT
Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca(2+) channel Orai1 and inducing Ca(2+) influx at the cell surface. Importantly, SPCA2-mediated Ca(2+) signaling is uncoupled from its conventional role of Ca(2+)-ATPase and independent of store-operated Ca(2+) signaling pathway. SPCA2-induced store-independent Ca(2+) entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
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Prognóstico
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Canais de Cálcio
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Transformação Celular Neoplásica
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ATPases Transportadoras de Cálcio
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Sinalização do Cálcio
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Proliferação de Células
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Proteína ORAI1
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Metabolismo
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Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
International Journal of Oral Science
Ano de publicação:
2013
Tipo de documento:
Article