Clinical study of zoledronic acid in the treatment of cancer-induced hypercalcemia / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 632-634, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-358550
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and safety of zoledronic acid (Zoledex) in patients with cancer-induced hypercalcemia.</p><p><b>METHODS</b>Seventeen patients with cancer-induced hypercalcemia (corrected blood calcium > 2.70 mmol/L) were treated intravenously by 4 mg zoledex within 15 minutes on the first day. The corrected blood calcium was observed every 4 days in the following 28 days.</p><p><b>RESULTS</b>The response rate was 94.1% (16/17). The mean corrected blood calcium became normal after the first dose of zoledex (P < 0.01). The lowest value was found on the fourteenth day after treatment. The main side effects consisted of fever (29.4%, 5/17), hypocalcemic tetany (11.8%, 2/17) and arythmia (5.9%, 1/17).</p><p><b>CONCLUSION</b>Zoledex is effective and safe in the treatment of patient with cancer-induced hypercalcemia.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Segurança
/
Usos Terapêuticos
/
Difosfonatos
/
Tratamento Farmacológico
/
Conservadores da Densidade Óssea
/
Hipercalcemia
/
Imidazóis
/
Neoplasias
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2005
Tipo de documento:
Artigo
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