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Transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 478-482, 2005.
Artigo em Chinês | WPRIM | ID: wpr-358598
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of transcatheter arterial chemoembolization (TACE) on the result and the prognosis of hepatocellular carcinoma (HCC) at systemic, cellular, genetic and molecular levels.</p><p><b>METHODS</b>Patients with histologically proven HCC were divided into two groups 81 patients in Group A undergoing TACE before operation and 58 patients in Group B treated with surgical resection alone. The degree of apoptosis was analyzed by transferase -mediated dUTP nick end labeling (TUNEL) stain. The expressions of bcl-2, bax, p53, Ki-67 and PCNA proteins were detected by immunohistochemical method. The changes of these markers, tumor necrosis, encapsulation, volume, metastasis, recurrence and cumulative survival in each group were retrospectively analyzed.</p><p><b>RESULTS</b>The more tumor necrosis, apoptosis, encapsulation and tumor shrinkage observed, and the less recurrence resulted from TACE in group A than in group B. The cumulative 1-, 2-, and 3-year survival rates and median survival time were 84.0%, 67.9%, 40.7%, and 803.3 days in group A patients; they were 72.4%, 55.2%, 24.1%, and 742.5 days in group B patients (P < 0.05).</p><p><b>CONCLUSION</b>Preoperative transcatheter arterial chemoembolization is safe and effective as an auxiliary preparatory means before surgical treatment of hepatocellular carcinoma as it may improve the survival of HCC patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Terapêutica / Protocolos de Quimioterapia Combinada Antineoplásica / Quimioembolização Terapêutica / Carcinoma Hepatocelular / Artéria Hepática / Neoplasias Hepáticas Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Terapêutica / Protocolos de Quimioterapia Combinada Antineoplásica / Quimioembolização Terapêutica / Carcinoma Hepatocelular / Artéria Hepática / Neoplasias Hepáticas Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Oncology Ano de publicação: 2005 Tipo de documento: Artigo