Energy power in mountains: difference in metabolism pattern results in different adaption traits in Tibetans / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 488-493, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-358707
ABSTRACT
Energy metabolism plays an important role in life survival for species living in high altitude hypoxia condition. Air-breathing organisms require oxygen to create energy. Tibetans are the well-adapted highlanders in Qinghai-Tibetan Plateau. It was thought that different metabolic approaches could lead to different adaptation traits to high altitude hypoxia. Recently identified hypoxia inducible factors pathway regulators, endothelial PAS domain protein1 (EPAS1)/HIF-2a and PPARA, were involved in decreasing hemoglobin concentrations in Tibetans. Because EPAS1 and PPARA also modulated the energy metabolism during hypoxia, we hypothesized that positive selected EPAS1 and PPARA genes were also involved in unique energy metabolisms in Tibetans. In this brief review, we take a look into genetic determinations to energy metabolisms for hypoxia adaptations traits in Tibetans and mal-adaptive conditions such as high altitude diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Fenótipo
/
Hemoglobinas
/
Tibet
/
Metabolismo Energético
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
/
Altitude
/
Genética
/
Aclimatação
/
Hipóxia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2012
Tipo de documento:
Artigo
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