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High-altitude hypoxia induces disorders of the brain-endocrine-immune network through activation of corticotropin-releasing factor and its type-1 receptors / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 481-487, 2012.
Artigo em Inglês | WPRIM | ID: wpr-358708
ABSTRACT
High-altitude hypoxia can induce physiological dysfunction and mountain sickness, but the underlying mechanism is not fully understood. Corticotrophin-releasing factor (CRF) and CRF type-i receptors (CRFR1) are members of the CRF family and the essential controllers of the physiological activity of the hypothalamo-pituitary-adrenal (HPA) axis and modulators of endocrine and behavioral activity in response to various stressors. We have previously found that high-altitude hypoxia induces disorders of the brain-endocrine-immune network through activation of CRF and CRFR1 in the brain and periphery that include activation of the HPA axis in a time- and dose-dependent manner, impaired or improved learning and memory, and anxiety-like behavioral change. Meanwhile, hypoxia induces dysfunctions of the hypothalamo-pituitary-endocrine and immune systems, including suppression of growth and development, as well as inhibition of reproductive, metabolic and immune functions. In contrast, the small mammals that live on the Qinghai-Tibet Plateau alpine meadow display low responsiveness to extreme high-altitude-hypoxia challenge, suggesting well-acclimatized genes and a physiological strategy that developed during evolution through interactions between the genes and environment. All the findings provide evidence for understanding the neuroendocrine mechanisms of hypoxia-induced physiological dysfunction. This review extends these findings.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sistema Hipófise-Suprarrenal / Encéfalo / Hormônio Liberador da Corticotropina / Receptores de Hormônio Liberador da Corticotropina / Tibet / Altitude / Sistema Hipotálamo-Hipofisário / Hipóxia / Metabolismo Limite: Animais País/Região como assunto: Ásia Idioma: Inglês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sistema Hipófise-Suprarrenal / Encéfalo / Hormônio Liberador da Corticotropina / Receptores de Hormônio Liberador da Corticotropina / Tibet / Altitude / Sistema Hipotálamo-Hipofisário / Hipóxia / Metabolismo Limite: Animais País/Região como assunto: Ásia Idioma: Inglês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2012 Tipo de documento: Artigo