Phenotyping human platelet antigens of the Kinh population in the centre, Vietnam

ABSTRACT

Located on the platelet membrane surface, human platelet specific antigens (HPAs) are related to alloimmune thrombocytopenic syndromes. The frequencies of HPA genes vary between different populations. In this study, the author initially identified HPA gene frequencies of Kinh population which are living in the Centre of Vietnam by polymerase chain reaction with specific sequence primers (PCR-SSP). The frequencies observed are following 0.977, 0.023, 0.000 for HPA-1a/a, HPA-1b/b; 0.827, 0.161, 0.011 for HPA-2a/a, HPA-2a/b, HPA-2b/b; 0.276, 0.552, 0.173 for HPA-3a/a, HPA-3a/b, HPA-3b/b; 0.920, 0.080, 0.000 for HPA-5a/a, HPA-5a/b, HPA-5b/b. respectively. For HPA-4, all 87 donor samples presented HPA-4a/a