Diagnostic value of SATB2, CK7 and CK20 in colorectal cancer / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 578-581, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-358962
ABSTRACT
<p><b>OBJECTIVE</b>To study the diagnostic value of SATB2, together with CK7 and CK20, in colorectal cancer.</p><p><b>METHODS</b>Immunohistochemical study for SATB2, CK7 and CK20 was carried out in 210 cases of colorectal cancer tissue, 100 cases of non-colorectal cancer tissue, 90 cases of lymph node metastases and 50 cases of normal colorectal mucosa.</p><p><b>RESULTS</b>The sensitivity and specificity of CK20+/CK7- immunophenotype for diagnosis of colorectal adenocarcinoma were 78.1% and 92.0%, respectively. When triple markers were used, the immunophenotype CK20+/CK7-/SATB2+ had a sensitivity of 57.1% and a specificity of 98.0%. When combining the immunophenotype of SATB2+/CK7- or CK20+/CK7-, the sensitivity was 85.7% and specificity was 90.0%.</p><p><b>CONCLUSIONS</b>A panel of immunohistochemical markers SATB2, CK7 and CK20 could increase the specificity for diagnosis of colorectal adenocarcinoma significantly. SATB2 is considered as a useful adjunct in this respect.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Biomarcadores Tumorais
/
Imunofenotipagem
/
Sensibilidade e Especificidade
/
Proteínas de Ligação à Região de Interação com a Matriz
/
Diagnóstico
/
Queratina-20
/
Queratina-7
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2015
Tipo de documento:
Artigo
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