Simulation of extracellular action potential for hippocampal pyramidal neurons / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1007-1013, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-359135
ABSTRACT
In order to extract more information from extracellular action potential (EAP) of neurons recorded deep in the brain tissue, we established simulation models of various pyramidal neurons in the hippocampal CA1 region and investigated the effects of dendrite currents, cell morphology and ion mechanisms on the formation of EAP waveforms. The results show that dendrite currents have significant effects on the EAP at the locations far from cell body, but not on those near cell body. The differences of shape of various pyramidal neurons result in large changes in the EAP amplitudes. However, the shapes of these different EAP are very similar. Ion mechanisms, such as calcium channels, have little effect on EAP waveforms. These results provide important information for experimental EAP recordings, EAP data analysis, and developing new methods to extract more neuronal data from EAP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Simulação por Computador
/
Potenciais de Ação
/
Células Piramidais
/
Biologia Celular
/
Hipocampo
/
Modelos Biológicos
/
Neurônios
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2011
Tipo de documento:
Artigo
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