20-year search on molecular markers of Leishmania isolates from different Kala-azar foci in China to confirm whether genetic fingerprints of Kala-azar pathogens correlate with disease types / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 997-1000, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-359137
ABSTRACT
Leishmaniasis (Kala-azar) from different endemic regions of China expresses different clinic and epidemiological features, and traditionally is classified as hilly, plain and desert types/foci. We concentrated our review on whether the pathogens from those foci were different at molecular level, if so, whether there are were molecular markers readily identifiable by molecular technologies. This was a review of a 20-year search for such markers by using kinetoplastic DNA (kDNA), nDNA hybridization, PCR-SSCP, RAPD and sequence analysis of SSU rDNA variable regions and LACK gene. The results showed that heterogeneities at molecular level exist in Leishmania isolated from different foci of China, which could be used as markers for different types of Leishmaniasis in China.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parasitologia
/
Leishmania donovani
/
China
/
Impressões Digitais de DNA
/
DNA de Protozoário
/
Classificação
/
Genética
/
Genótipo
/
Leishmaniose Visceral
/
Mutação
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2011
Tipo de documento:
Artigo
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