Acquired factor V inhibitor: 3 cases report and literature review / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 294-298, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-359503
ABSTRACT
<p><b>OBJECTIVE</b>To better understand the acquired factor V (FV) inhibitors.</p><p><b>METHODS</b>The clinical features, laboratory manifestations, treatment options and prognosis of 3 cases were reported and related literature were reviewed.</p><p><b>RESULTS</b>All the 3 patients were older than 50 years without family history and related disease. Their clinical manifestations included spontaneously mucous bleeding, hematuria, epistaxis and encephalic bleeding. Laboratory test showed prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT). The FV levels decreased and the presence of FV inhibitor was confirmed by Bethesda method. All patients were treated with glucocorticoid and immunosuppressive agents. The haemorrhages of two patients stopped but their coagulation test and FV level recovered slowly. One patient died from encephalic bleeding.</p><p><b>CONCLUSIONS</b>Acquired FV inhibitor is a rare coagulation disorder with variable clinical symptoms. Immunosuppressive agents are effective to eliminate the inhibitors. The prognosis of acquired FV inhibitors seemed to be strictly related to the basic disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fator V
/
Transtornos de Proteínas de Coagulação
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2012
Tipo de documento:
Artigo
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