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Expression and clinical significance of ID1 gene in acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology ; (12): 278-281, 2012.
Artigo em Chinês | WPRIM | ID: wpr-359507
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression and clinical significance of ID1 gene in acute myeloid leukemia (AML) patients.</p><p><b>METHOD</b>Real-time quantitative PCR (RQ-PCR) was used to test the expression level of ID1 gene in 114 de novo adult AML patients, and the clinical features of these patients were analyzed.</p><p><b>RESULTS</b>ID1 gene transcript levels were detectable in BM mononuclear cells from 114 patients with AML, the median expression level of all samples was 8525 (range 57 - 11 233 238). There was a statistically significant difference on expression level of ID1 gene among the three different cytogenetic prognosis groups, and the poor prognosis group (median 36 840, range 336 - 11 233 238) harbored the significantly higher level of ID1 gene than the intermediate prognosis group (Median 6630, range 66 - 1 840 798) (P = 0.006). The expression level of ID1 gene was positively associated with older age (age ≥ 60 years vs < 60 years, P = 0.002) and higher WBC count (WBC ≥ 10×10(9)/L vs < 10×10(9)/L, P = 0.005). Young patients (age < 60 years) who were not obtained the complete remission (non-CR) after the first cycle of chemotherapy harbored the high level of ID1 gene (Median 9537 of non-CR vs 1268 of CR, P = 0.010).</p><p><b>CONCLUSIONS</b>High expression level of ID1 gene was mostly seen in AML patients with adverse cytogenetics and older age (age ≥ 60 years), and may be associated with poor prognosis of AML. ID1 gene might be a prognostic molecular marker of AML.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Leucemia Mieloide Aguda / Estudos de Casos e Controles / Diagnóstico / Proteína 1 Inibidora de Diferenciação / Genética / Metabolismo Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Leucemia Mieloide Aguda / Estudos de Casos e Controles / Diagnóstico / Proteína 1 Inibidora de Diferenciação / Genética / Metabolismo Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Hematology Ano de publicação: 2012 Tipo de documento: Artigo