Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 475-479, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-359623
ABSTRACT
Cardiovascular disease is a severe threat to human health and life. Among many risk factors of cardiovascular disease, genetic or gene-based ones are drawing more and more attention in recent years. Accumulated evidence has demonstrated that the loss or mutation of ataxia telangiectasia mutated (ATM) gene can result in DNA damage repair dysfunctions, telomere shortening, decreased antioxidant capacity, insulin resistance, increased lipid levels, etc., and thus can promote the occurrence of cardiovascular risk factors, such as aging, atherosclerosis and metabolic syndrome. In this review, we discusses the possible mechanisms between ATM gene and cardiovascular risk factors, which could be helpful to the related research and clinical application.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dano ao DNA
/
Envelhecimento
/
Doenças Cardiovasculares
/
Fatores de Risco
/
Reparo do DNA
/
Proteínas Mutadas de Ataxia Telangiectasia
/
Genética
/
Mutação
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2015
Tipo de documento:
Artigo
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