Transmission disequilibrium test for nonsyndromic cleft lip and palate and segment homeobox gene-1 gene / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 561-563, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-359694
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between muscle segment homeobox gene-1 (MSX1) and the genetic susceptibility of nonsyndromic cleft lip and palate (NSCLP) in Hunan Hans.</p><p><b>METHODS</b>One microsatellite DNA marker CA repeat in MSX1 intron region was used as genetic marker. The genotypes of 387 members in 129 NSCLP nuclear family trios were analyzed by polymerase chain reaction (PCR) and denaturing polyacrylamide gel electrophoresis. Then transmission disequilibrium test (TDT) and Logistic regression analysis were used to conduct association analysis.</p><p><b>RESULTS</b>TDT analysis confirmed that CA4 allele in CL/P and CPO groups preferentially transmitted to the affected offspring (P = 0.018, P = 0.041). Logistic regression analysis indicated that the recessive model of inheritance was supported, and CA4 itself or CA4 acting as a marker for a disease allele or haplotype was inherited in a recessive fashion (P = 0.009).</p><p><b>CONCLUSIONS</b>MSX1 gene is associated with NSCLP, and MSX1 gene may be directly involved either in the etiology of NSCLP or in linkage disequilibrium with disease-predisposing sites.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linhagem
/
Marcadores Genéticos
/
Desequilíbrio de Ligação
/
Modelos Logísticos
/
Fenda Labial
/
Fissura Palatina
/
Repetições de Microssatélites
/
Povo Asiático
/
Fator de Transcrição MSX1
/
Genética
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2007
Tipo de documento:
Artigo
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