Age-related decrease in aromatase and estrogen receptor (ERalpha and ERbeta) expression in rat testes: protective effect of low caloric diets / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 177-187, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-359972
ABSTRACT
<p><b>AIM</b>To examine the effects on rat aging of caloric restriction (CR1) and undernutrition (CR2) on the body and on testicular weights, on two enzymatic antioxidants (superoxide dismutase and catalase), on lipid peroxidation and on the expression of testicular aromatase and estrogen receptors (ER).</p><p><b>METHODS</b>CR was initiated in 1-month-old rats and carried on until the age of 18 months.</p><p><b>RESULTS</b>In control and CR2 rats an age-related decrease of the aromatase and of ER (alpha and beta) gene expression was observed; in parallel a diminution of testicular weights, and of the total number and motility of epididymal spermatozoa was recorded. In addition, aging in control and CR2 rats was accompanied by a significant decrease in testicular superoxide dismutase, catalase activities, and an increase in lipid peroxidation level (thiobarbituric acid reactive substance), associated with alterations of spermatogenesis. Conversely, caloric restriction-treatment exerted a protective effect and all the parameters were less affected by aging.</p><p><b>CONCLUSION</b>These results indicate that during aging, a low caloric diet (not undernutrition) is beneficial for spermatogenesis and likely improves the protection of the cells via an increase of the cellular antioxidant defense system in which aromatase/ER could play a role.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Superóxido Dismutase
/
Testículo
/
Envelhecimento
/
Aromatase
/
Peroxidação de Lipídeos
/
Catalase
/
Regulação para Baixo
/
Expressão Gênica
/
Fatores Etários
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Artigo
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