Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 54-59, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-360003
ABSTRACT
Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies for the cavernous nerves (CNs), as therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function. Nitric oxide released from the axonal end plates of these nerves within the corpora cavernosa causes relaxation of smooth muscle, initiating the haemodynamic changes of penile erection as well as contributing to maintained tumescence; the loss of CN function is primarily responsible for the development of erectile dysfunction (ED) after pelvic surgery and serves as the primary target for potential neuroprotective or regenerative strategies. Evidence from pre-clinical studies for select neuromodulatory approaches is reviewed, including neurotrophins, glial cell line-derived neurotrophic factors (GDNF), bone morphogenic proteins, immunophilin ligands, erythropoetin (EPO), and stem cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pênis
/
Complicações Pós-Operatórias
/
Terapêutica
/
Eritropoetina
/
Neurotransmissores
/
Fator Neurotrófico Derivado do Encéfalo
/
Proteínas Morfogenéticas Ósseas
/
Imunofilinas
/
Transplante de Células-Tronco
/
Usos Terapêuticos
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Artigo
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