Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Treating Patient with Primary Cutaneous γΔ T Cell Lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 749-754, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-360014
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical characteristics of primary cutaneous γΔ T cell lymphoma and its treatment methods.</p><p><b>METHODS</b>The clinical data and treatment process of one woman case of primary cutaneous γ Δ T cell lymphoma diagnosed in our department were analysed. The multiple subcutaneous nodules were the main clinical features, the diagnosis of primary cutaneous γΔ T cell lymphoma was comfired by skin biopsy pathology. The immunophenotypes of lymphocytes showed CD20-, CD3+, CD4-, CD8-, CD56+, TIA-1+, Ki-67+ (about 60%); plasma cells kappa+(part)/lambda predominate+(part); histocytes CD4+, CD68/PGM1+; βF1-, epstein-barr (EB) virus showed negative EBER in situ hybridization.</p><p><b>RESULTS</b>By means of the chemotherapy regimens containing L-Asparaginase, the complete remission (CR) was achieved. Then, the patients were given autologous hematopoietic stem cell transplantation. Neutrophils were implanted after 16 days, and platelet was implanted after 18 days. Now, the patient is still in remission.</p><p><b>CONCLUSION</b>primary cutaneous γΔ T cell lymphoma is rare and easy to be misdiagnosed. This disease is aggressive and its prognosis is poor. The large dose chemotherapy with L-asparaginase shows a certain curative efficacy, the autologous hematopoietic stem cells can prolong survival time of the patient.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asparaginase
/
Terapêutica
/
Transplante Autólogo
/
Indução de Remissão
/
Imunofenotipagem
/
Linfoma Cutâneo de Células T
/
Herpesvirus Humano 4
/
Transplante de Células-Tronco Hematopoéticas
/
Usos Terapêuticos
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2016
Tipo de documento:
Artigo
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