Clinical Therapy and Prognostic Analysis of 61 Patients with Secondary Hemophagocytic Syndrome / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between the etiology, laboratory findings and prognosis of secondary HPS, so as to enhance the understanding of the secondary HPS and the related factors affecting prognosis, reduce the misdiagnosis and to understand the factors that affect the prognosis.</p><p><b>METHODS</b>The etiology, laboratory findings and prognosis of 61 patients with secondary HPS were analyzed retrospectively.</p><p><b>RESULTS</b>Univariate analysis showed that TG, FIB, SF, ANC, ALB, TBIL, ALT, LDH were significantly different between the 2 groups of the patients with secondary HPS. Multiariate factor analysis showed that the LDH and the etiology affected the prognosis of the patients with secondary HPS. The prognosis of the patients with elevated LDH, viral infection, especially EB virus infection, tumor and unknown causes might be poor.</p><p><b>CONCLUSIONS</b>The etiology and clinical characteristics of prognosis are diverse. The cause needs to be identified as soon as possible. The prognosis should be judged according to LDH and other indicators. Then, targeted therapy should be used to control the disease in the short time.</p>