Research Progress on Drug-resistance of Acute Lymphoblastic Leukemia--Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 261-265, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-360105
ABSTRACT
Acute lymphoblastic leukemia (ALL) is a malignant clonal disease, its treatment methods include chemotherapy, hematopoietic stem cell transplantation, immunotherapy and molecular targeted therapy. Clinically, ALL patients need to get complete remission through chemotherapy, and then choose the other treatment according to the patient's condition. But the drug resistance has been a biggest obstacle in treatment of ALL. There are many research reports about drug-resistant of ALL at present. In this review, the classic drug resistance mechanisms, such as membrane transporter, gene modifications and some newly finding mechanisms including such as bone marrow microenvironment and Micro RNA and so on are summarized.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas de Membrana Transportadoras
/
Fisiologia
/
Medula Óssea
/
Resistencia a Medicamentos Antineoplásicos
/
MicroRNAs
/
Tratamento Farmacológico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Microambiente Celular
/
Genética
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2016
Tipo de documento:
Artigo
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