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Effects of cryptotanshinone in lowering androgens synthesis for the prenatally androgenized male rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 1001-1004, 2008.
Artigo em Chinês | WPRIM | ID: wpr-360503
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of cryptotanshinone on androgen synthesis for the prenatally androgenized male rats.</p><p><b>METHODS</b>On days 16-18 of pregnancy, rats were injected s. c. with testosterone propionas continuously for 3 days; male offspring were studied as subject. Serum concentrations of testosterone (T), 17a-hydroxy progesterone (17-OHP), blood glucose, and insulin were measured by radioimmunoassay. Then, the rats were treated with cryptotanshinone by gavage for 14 days, and the levels of serum T, 17-OHP and insulin were detected and the 17a-hydroxylase protein expression in interstitial cell was measured using the method of immunohistochemistry.</p><p><b>RESULTS</b>There was no difference between the male groups who were prenatally androgenized in serum levels of T, but the 17-OHP, fasting insulin levels and homeostatic model assessment for insulin resistance (HOMA-IR) elevated significantly (P < 0.05). Cryptotanshinone could lower the levels of 17-OHP (P < 0.05) but had no effect on 17a-hydroxylase.</p><p><b>CONCLUSION</b>Prenatally androgenized male rats exhibit elevated 17-OHP and diminished insulin sensitivity. Cryptotanshinone could decrease 17-OHP, but has no effect on insulin, indicating it may reduce androgen synthesis.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenantrenos / Síndrome do Ovário Policístico / Efeitos Tardios da Exposição Pré-Natal / Distribuição Aleatória / Ratos Wistar / Exposição Materna / Modelos Animais de Doenças / Tratamento Farmacológico / Androgênios / Metabolismo Tipo de estudo: Ensaio Clínico Controlado Limite: Animais / Feminino / Humanos / Masculino / Gravidez Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenantrenos / Síndrome do Ovário Policístico / Efeitos Tardios da Exposição Pré-Natal / Distribuição Aleatória / Ratos Wistar / Exposição Materna / Modelos Animais de Doenças / Tratamento Farmacológico / Androgênios / Metabolismo Tipo de estudo: Ensaio Clínico Controlado Limite: Animais / Feminino / Humanos / Masculino / Gravidez Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2008 Tipo de documento: Artigo