Association of estrogen receptor-alpha gene Pvull polymorphisms with the effect of calcium supplementation on skeletal development in Chinese pubertal girls / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 480-487, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-360637
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of estrogen receptor alpha (ER-alpha) PvuII polymorphisms with the effect of calcium supplementation on bone development in Chinese pubertal girls, and to study the importance of calcium supplementation by maximizing the peak bone mass at their pubertal stage for bone development and osteoporosis prevention and the role of estrogen in regulating bone mass.</p><p><b>METHODS</b>Ninety-four pubertal girls were recruited in the study and divided into two groups and three sub-groups according to the ER-alpha PvuII polymorphisms. One year before and after calcium supplementation, bone mineral density (BMD) was measured by DEXA, while BGP, BAP, TRACP5b, and 25-OH-VitD(3), as well as estrogen were detected by ELISA. Analysis of covariance was used to examine the effect of ER-alpha polymorphisms on bone development.</p><p><b>RESULTS</b>The absolute increase and percentage change of BGP were significantly higher in the supplemented group than in the control group (P<0.05). In the intervened group, The increase and percentage change of the total body and radio distal 1/3 BMD were higher in PP than in PP genotype (P<0.05), and the increase of BAP in Pp was also higher than PP in the same group (P<0.05).</p><p><b>CONCLUSION</b>PP genotype shows a better response to calcium supplementation than the other PvuII polymorphisms.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Polimorfismo Genético
/
Biomarcadores
/
Densidade Óssea
/
Cálcio
/
Puberdade
/
Suplementos Nutricionais
/
Povo Asiático
/
Receptor alfa de Estrogênio
Limite:
Adolescente
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2009
Tipo de documento:
Artigo
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