Gene expression profile of human skeletal muscle and adipose tissue of Chinese Han patients with type 2 diabetes mellitus / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 359-368, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-360653
ABSTRACT
<p><b>OBJECTIVE</b>To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and healthy subjects using DNA microarray analysis.</p><p><b>METHODS</b>T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to analyze the relation between gene expressions and T2DM.</p><p><b>RESULTS</b>The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was > or = 2 folds. These differentially expressed genes were classified into 15 categories according to their functions.</p><p><b>CONCLUSION</b>New genes are found and T2DM can be prevented or cured.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Tecido Adiposo
/
Regulação da Expressão Gênica
/
Músculo Esquelético
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Perfilação da Expressão Gênica
/
Povo Asiático
/
Diabetes Mellitus Tipo 2
/
Metabolismo
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2009
Tipo de documento:
Artigo
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