Red yeast rice increases excretion of bile acids in hamsters / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 269-277, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-360665
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism.</p><p><b>METHODS</b>Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography.</p><p><b>RESULTS</b>Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7alpha-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value.</p><p><b>CONCLUSION</b>Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho do Órgão
/
Farmacologia
/
Produtos Biológicos
/
Sangue
/
Peso Corporal
/
Ácidos e Sais Biliares
/
Receptores de LDL
/
Colesterol 7-alfa-Hidroxilase
/
Aumento de Peso
/
Química
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2009
Tipo de documento:
Artigo
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