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The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues / 中华外科杂志
Chinese Journal of Surgery ; (12): 1104-1107, 2004.
Artigo em Chinês | WPRIM | ID: wpr-360921
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cyclooxygenase-2 (COX-2) in bladder transitional cell carcinoma tissues, and understand its clinical significance.</p><p><b>METHODS</b>Reversal transcription polymerase chain reaction (RT-PCR) was used to assess the expression of COX-2 mRNA in 52 cases of bladder transitional cell carcinoma tissues and 17 cases of normal bladder tissues far from neoplasm; Western blot was used to assess the expression of COX-2 protein in 49 cases of bladder cancerous tissues and 17 cases of normal tissues.</p><p><b>RESULTS</b>Positive expression of COX-2 mRNA was detected in 83% (43/52) of bladder cancer tissues and in 29% (5/17) of normal tissues by RT-PCR and there was significant difference in expression of COX-2 mRNA between cancer tissues and normal tissues. Western blot analysis showed that expression of COX-2 protein was correlation with the stage and grade of cancer.</p><p><b>CONCLUSION</b>COX-2 is overexpressed in bladder transitional cell carcinoma. COX-2 maybe play a certain role in carcinogenesis and progression of bladder cancer and turn into a useful target of chemoprevention of bladder cancer.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Bexiga Urinária / Neoplasias da Bexiga Urinária / RNA Mensageiro / Carcinoma de Células de Transição / Western Blotting / Reação em Cadeia da Polimerase Via Transcriptase Reversa / Ciclo-Oxigenase 2 / Genética / Estadiamento de Neoplasias Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Surgery Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Bexiga Urinária / Neoplasias da Bexiga Urinária / RNA Mensageiro / Carcinoma de Células de Transição / Western Blotting / Reação em Cadeia da Polimerase Via Transcriptase Reversa / Ciclo-Oxigenase 2 / Genética / Estadiamento de Neoplasias Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Surgery Ano de publicação: 2004 Tipo de documento: Artigo