The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1104-1107, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-360921
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cyclooxygenase-2 (COX-2) in bladder transitional cell carcinoma tissues, and understand its clinical significance.</p><p><b>METHODS</b>Reversal transcription polymerase chain reaction (RT-PCR) was used to assess the expression of COX-2 mRNA in 52 cases of bladder transitional cell carcinoma tissues and 17 cases of normal bladder tissues far from neoplasm; Western blot was used to assess the expression of COX-2 protein in 49 cases of bladder cancerous tissues and 17 cases of normal tissues.</p><p><b>RESULTS</b>Positive expression of COX-2 mRNA was detected in 83% (43/52) of bladder cancer tissues and in 29% (5/17) of normal tissues by RT-PCR and there was significant difference in expression of COX-2 mRNA between cancer tissues and normal tissues. Western blot analysis showed that expression of COX-2 protein was correlation with the stage and grade of cancer.</p><p><b>CONCLUSION</b>COX-2 is overexpressed in bladder transitional cell carcinoma. COX-2 maybe play a certain role in carcinogenesis and progression of bladder cancer and turn into a useful target of chemoprevention of bladder cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
RNA Mensageiro
/
Carcinoma de Células de Transição
/
Western Blotting
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Ciclo-Oxigenase 2
/
Genética
/
Estadiamento de Neoplasias
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2004
Tipo de documento:
Artigo
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