Response of masticatory muscles to passive stretch stimulus - from perspectives of functional appliances / 대한치과교정학회지
The Korean Journal of Orthodontics
;
: 64-72, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-36135
ABSTRACT
OBJECTIVE:
The aims of this study were to examine whether a passive stretch stimulus by means of a functional appliance induces changes in the fiber composition of masticatory muscles and whether these changes are similar to the changes in stretched limb muscle fibers by using RT-PCR, western blot, and immunohistochemical assays.METHODS:
Five male New Zealand White rabbits were fitted with a prefabricated inclined plane on the maxillary central incisors to force the mandible forward (- 2 mm) and downward (- 4 mm). Further, 1 hind limb was extended and constrained with a cast so that the extensor digitorum longus (EDL) was stretched when the animal used the limb. The animals were sacrificed after 1 week and the masseter, lateral pterygoid, and EDL were processed and compared with those from control animals (n = 3).RESULTS:
The stretched EDL had a significantly higher percentage of slow fibers, whereas the stretched masticatory muscles did not show changes in the composition of the major contractile proteins after 7 days.CONCLUSIONS:
The transition of fiber phenotypes in response to a stretch stimulus may take longer in the masticatory muscles than in the limb muscles.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Western Blotting
/
Cadeias Pesadas de Miosina
/
Proteínas Contráteis
/
Extremidades
/
Incisivo
/
Mandíbula
/
Músculos da Mastigação
/
Músculos
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Orthodontics
Ano de publicação:
2012
Tipo de documento:
Artigo
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