Renal Function after Cardiopulmonary Bypass and Effect of Urinastatin on Renal Function / 日本心臓血管外科学会雑誌

ABSTRACT

To evaluate the renal function after cardiopulmonary bypass (CPB) and the effect of Urinastatin on renal function, the tubular and glomerular damage were studied in patients underwent cardiac operations, dividing following two groups; Group U with Urinastain and Group C without Urinastatin. Of indexes of glomerular function, changes in serum creatinine and urine nitrogen, and creatinine clearance did not show remarkably after CPB. Serum β₂-microglobulin indicating glomerular function after CPB demonstrated significantly higher levels than that before operation in Group C, but did not in Group U. N-acetyl-β3-D-glucosaminidase and γ-glutamyl-transpeptidase in urine as markers of tubular function rose significantly after CPB in both groups, but they showed significantly lower level in Group U than in Group C. After CPB, even in patients without clinical renal failure, glomerular and tubular dysfunction were placed. Urinastatin was considered to be effective in protection of glomerular and tubular function.