Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 434-438, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-36822
ABSTRACT
BACKGROUND:
Gabapentin and pregabalin are antiepileptic drugs that are also used for chronic pain treatment. This study evaluated the effects of pregabalin and gabapentin on postoperative pain in patients undergoing laparoscopic cholecystectomy.METHODS:
A total of 108 candidates for elective laparoscopic cholecystectomy were randomly assigned to gabapentin (n = 36), pregabalin (n = 36), and placebo (n = 36) groups. Patients received 800 mg of gabapentin or 150 mg of pregabalin orally one hour before surgery. Postoperative analgesia was administered by pethidine via patient-controlled analgesia. The amount of opioid consumed, number of nausea events, vomiting, and pain scores at 2, 6, 12, and 24 hours after surgery were recorded.RESULTS:
The gabapentin and pregabalin groups had significantly lower pain intensity than the placebo group, and pain intensity in the pregabalin group decreased more compared to the gabapentin group. The mean amount of pethidine consumption in the placebo group was significantly higher than in the gabapentin and pregabalin groups.CONCLUSIONS:
A single dose of gabapentin or pregabalin decreased postoperative pain and nausea, as well as vomiting and opioid consumption after laparoscopic cholecystectomy. Moreover, the findings revealed that pregabalin was superior to gabapentin for reducing postoperative pain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor Pós-Operatória
/
Vômito
/
Colecistectomia
/
Analgesia Controlada pelo Paciente
/
Colecistectomia Laparoscópica
/
Dor Crônica
/
Pregabalina
/
Analgesia
/
Meperidina
/
Anticonvulsivantes
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2017
Tipo de documento:
Artigo
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