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Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study / 대한마취과학회지
Korean Journal of Anesthesiology ; : 426-433, 2017.
Artigo em Inglês | WPRIM | ID: wpr-36823
ABSTRACT

BACKGROUND:

Dexmedetomidine is a highly selective central α₂-agonist used as a sedative in pediatric intensive care unit (PICU). However, little is known about the relationship between dexmedetomidine dose and its plasma concentration during long-term infusion. We have previously demonstrated that the sedative plasma dexmedetomidine concentration is moderately correlated with the administered dose in adults (r = 0.653, P = 0.001). We hypothesized that there would be a similar relationship between the sedative dexmedetomidine concentration and administered dose in infants.

METHODS:

All patients admitted to the PICU at Nagoya City University Hospital, Japan, between November 2012 and March 2013 were eligible for inclusion in the study. Plasma dexmedetomidine concentration was measured by ultra-performance liquid chromatography coupled with tandem mass spectrometry.

RESULTS:

We measured the plasma dexmedetomidine concentration in 203 samples from 45 patients. Of these, 96 samples collected from 27 patients < 2 years old were included in this study. All patients received dexmedetomidine at 0.12–1.40 µg/kg/h. The median administration duration was 87.6 hours (range 6–540 hours). Plasma dexmedetomidine concentration ranged from 0.07 to 3.17 ng/ml. Plasma dexmedetomidine concentration was not correlated with the administered dose (r = 0.273, P = 0.007). The approximate linear equation was y = 0.690x + 0.423.

CONCLUSIONS:

In infants, plasma dexmedetomidine concentration did not exhibit any correlation with administered dose, which is not a reliable means of obtaining optimal plasma concentration.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Estudos Prospectivos / Estudos de Coortes / Cromatografia Líquida / Estado Terminal / Dexmedetomidina / Espectrometria de Massas em Tandem / Unidades de Terapia Intensiva / Japão Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Fatores de risco Limite: Adulto / Humanos / Lactente País/Região como assunto: Ásia Idioma: Inglês Revista: Korean Journal of Anesthesiology Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Estudos Prospectivos / Estudos de Coortes / Cromatografia Líquida / Estado Terminal / Dexmedetomidina / Espectrometria de Massas em Tandem / Unidades de Terapia Intensiva / Japão Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Fatores de risco Limite: Adulto / Humanos / Lactente País/Região como assunto: Ásia Idioma: Inglês Revista: Korean Journal of Anesthesiology Ano de publicação: 2017 Tipo de documento: Artigo