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A case of encephalitis in a juvenile rheumatoid arthritis patient treated with etanercept / 소아과
Korean Journal of Pediatrics ; : 262-266, 2010.
Artigo em Inglês | WPRIM | ID: wpr-37357
ABSTRACT
Tumor necrosis factor-alpha (TNF-alpha) is a major proinflammatory cytokine involved in the pathophysiology of juvenile rheumatoid arthritis. Etanercept is an effective inhibitor of TNF-alpha and has shown a beneficial effect in patients with JRA. However, the most important cause of concern related to etanercept administration is infection. We report a case of encephalitis in a JRA patient receiving long-term treatment with etanercept. The patient was a 4-year-old boy with refractory JRA, and he received etanercept subcutaneously at a dose of 0.4 mg kg(-1) day(-1) twice a week for 14 months, along with non-steroidal anti-inflammatory drugs, methotrexate, oral steroids, and sulfasalazine. The patient presented with sudden fever, headache, vomiting, a generalized tonic seizure, and changes in mental status. We suspected a central nervous system infection, and simultaneously administered antibiotics, an antiviral agent, and steroids. After 2 days of hospitalization, his mental function returned to normal, and he showed no further seizure-like movements. Brain magnetic resonance imaging scan of the patient showed a multifocal cortical lesion on both sides of the temporoparietooccipital lobe, which indicated encephalitis. Although we were unable to identify the causative organism of encephalitis, we think that the encephalitis may be attributed to infection, and the use of etanercept may have increased the risk of severe infection. Therefore, etanercept was discontinued and the patient recovered shortly after. To the best of our knowledge, this is the first case of encephalitis in a juvenile rheumatoid arthritis patient treated with etanercept.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artrite Juvenil / Sulfassalazina / Convulsões / Esteroides / Vômito / Encéfalo / Imunoglobulina G / Imageamento por Ressonância Magnética / Infecções do Sistema Nervoso Central / Pré-Escolar Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Korean Journal of Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artrite Juvenil / Sulfassalazina / Convulsões / Esteroides / Vômito / Encéfalo / Imunoglobulina G / Imageamento por Ressonância Magnética / Infecções do Sistema Nervoso Central / Pré-Escolar Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Korean Journal of Pediatrics Ano de publicação: 2010 Tipo de documento: Artigo