Characteristics and mechanisms of low-frequency muscle fatigue: alterations in skeletal muscle / 体力科学
Japanese Journal of Physical Fitness and Sports Medicine
;
: 297-306, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-374218
ABSTRACT
Repeated contractions of skeletal muscle cause fatigue, as manifested by a reduced ability to produce force and slowed contraction. During studies of muscle fatigue, a phenomenon known as low-frequency fatigue (LFF) was observed in human skeletal muscles. It is characterized by a greater loss of force in response to low- versus high-frequency muscle stimulation and a long period of time for full recovery. This force deficit is most likely to be owing to disturbances in sarcoplasmic reticulum (SR) Ca<sup>2+</sup> release and/or reductions in myofibrillar Ca<sup>2+</sup> sensitivity. Studies on metabolites have implied that inorganic phosphate and Mg<sup>2+</sup> might have some role in reduced SR Ca<sup>2+</sup> release that occurs immediately after fatiguing contraction. In addition, recent experiments have shown that impaired myofibril function may relate to increased nitric oxide and hydroxyl radical production, whereas deterioration of SR function may be attributable to increased superoxide production, elevation of cytoplasmic Ca<sup>2+</sup> concentration and/or decreased muscle glycogen. Finally, we will discuss possible proteins which are affected and contribute to the development of LFF.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Japanese Journal of Physical Fitness and Sports Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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