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99mTc-HMPAO-labelled Leucocyte Scintigraphy in the Diagnosis of Infection after Total Knee Replacement Arthroplasty / 대한핵의학회잡지
Korean Journal of Nuclear Medicine ; : 413-421, 1999.
Artigo em Coreano | WPRIM | ID: wpr-37534
ABSTRACT

PURPOSE:

This study was performed to evaluate the usefulness of 99mTc-HMPAO-labelled leucocyte scintigraphy for diagnosing prosthetic infection after total knee replacement arthroplasty without the aid of following bone marrow scintigraphy. MATERIALS AND

METHODS:

The study subjects were 25 prostheses of 17 patients (one man and 16 women, mean age 65 years) who had total knee replacement arthroplasty. After injection of 99mTc-HMPAO-labelled leucocyte, the whole body planar and knee SPECT images were obtained in all patients. The subjects were classified into three groups according to clinical suspicion of prosthetic infection Group A (n=11) with high suspicion of infection; Group B (n=6) with equivocal suspicion of infection, and Group C (n=8) with asymptomatic contralateral prostheses. Final diagnosis of infection was based on surgical, histological and bacteriological data and clinical follow-up.

RESULTS:

Infection was confirmed in 13 prostheses (11 in Group A and 2 in Group B). All prostheses in Group A were true positive. There were two true positives, one false positive and three true negatives in Group B, and six true negatives and two false positives in Group C. Overall sensitivity, specificity, and accuracy for diagnosis of the infected knee prosthesis were 100%, 75% and 88%, respectively.

CONCLUSION:

99mTc-HMPAO-labelled leucocyte scintigraphy is a sensitive method for the diagnosis of infected knee prosthesis. However, false positive uptakes even in asymptomatic prosthesis suggest that bone marrow scintigraphy may be needed to achieve improved specificity.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artroplastia / Próteses e Implantes / Medula Óssea / Cintilografia / Tomografia Computadorizada de Emissão de Fóton Único / Seguimentos / Sensibilidade e Especificidade / Artroplastia do Joelho / Diagnóstico / Inflamação Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Nuclear Medicine Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artroplastia / Próteses e Implantes / Medula Óssea / Cintilografia / Tomografia Computadorizada de Emissão de Fóton Único / Seguimentos / Sensibilidade e Especificidade / Artroplastia do Joelho / Diagnóstico / Inflamação Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Nuclear Medicine Ano de publicação: 1999 Tipo de documento: Artigo