Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus
Immune Network
;
: 115-124, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-37604
ABSTRACT
BACKGROUND:
The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined.METHODS:
The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines.RESULTS:
The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines.CONCLUSION:
These results suggest that the exo- secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Quimiotaxia
/
Citocinas
/
Linhagem Celular Tumoral
/
Carga Tumoral
/
Aminoácidos
/
Leucócitos
/
Camundongos Endogâmicos ICR
/
Monossacarídeos
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Immune Network
Ano de publicação:
2002
Tipo de documento:
Artigo
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