Purification and Antihypertensive Activity of a Novel Angiotensin-I Converting Enzyme Inhibitory Peptide from Fish Sauce, <i>Ishiru</i> / 日本補完代替医療学会誌
Japanese Journal of Complementary and Alternative Medicine
;
: 45-49, 2013.
Artigo
em Japonês
| WPRIM
| ID: wpr-376368
ABSTRACT
We purified a novel angiotensin-I converting enzyme (ACE) inhibitor from fish sauce <i>Ishiru</i> prepared from squid, and identified it as the tripeptide Leu-Ala-Arg (LAR). IC<sub>50</sub> of this ACE inhibitor was 2.5 μM, demonstrating high potency among peptides previously purified from fish sauces. Moreover, LAR acted as an antihypertensive peptide, reducing systolic blood pressure in spontaneously hypertensive rats.<br>
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Japonês
Revista:
Japanese Journal of Complementary and Alternative Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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