<b>Effect of Saireito for Prevention and Improvement of Urethral Stricture after Transurethral Resection of the Prostate</b> / 日本東洋医学雑誌

ABSTRACT

<p><b>Objectives </b> We examined effect of saireito for prevention and improvement of urethral strictures after transurethral resection of the prostate (TUR-P), also examining the utility of considering the saireito ‘pattern'.<br><b>Materials and Methods </b> We evaluated 142 benign prostatic hyperplasia patients, and were randomly assigned to a saireito treatment group (3.0 gr. x 3 times per day 30 min. before meal, n = 70) and no treatment control group (n = 72).<br><b>Results </b> 1) A statistically significant difference was observed in the occurrence of urethral stricture by saireito administration (p = 0.043, Chi-square test, Odds ratio 0.12 [95% CI ; 0.01-0.95]. 2) For urethral strictures that occurred in the no treatment group, improvement of stricture in five cases was observed by saireito administration. 3) With either the appropriate administration or non-administration of saireito according to correct ‘pattern' diagnoses, the incidence of urethral stricture was significantly reduced (p = 0.042).<br><b>Discussion </b> Administration of saireito after TUR-P is effective for preventing post-operative urethral stricture. It is also effective for confirmed strictures. Saireito administration is appropriate in patients with saireito ‘pattern' indications.</p>