Nerve growth factor(NGF) induces mRNA expression of the new transcription factor protein p48ZnF
Experimental & Molecular Medicine
;
: 130-134, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-37856
ABSTRACT
Apoptosis, the cell's intrinsic death program, plays a crucial role in the regulation of tissue homeostasis, and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas excessive cell death is implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Using cDNA subtraction analysis, we compared p60TRP (p60 transcription regulator protein) expressing cells with control cells during the process of apoptosis and we identified the new zinc-finger protein p48ZnF that is predominantly located in the cytoplasm of the cell. Additionally, we demonstrate here that p48ZnF is up-regulated in rat neuronal PC12 cells upon stimulation with the neurotrophic factor NGF (50 ng/ml). These findings point to a possible pivotal role of p48ZnF in the control of neuronal survival.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Fatores de Transcrição
/
RNA Mensageiro
/
Dados de Sequência Molecular
/
Sequência de Bases
/
Transfecção
/
Biomarcadores
/
Sobrevivência Celular
/
Regulação da Expressão Gênica
/
Dedos de Zinco
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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