Expressions of VEGF-C and VEGFR-3 in non-small cell lung cancer and the relationship with lymph node metastasis / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 52-54, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-380095
ABSTRACT
Objective To study the expression of vascular endothelial growth factor-C (VEGF-C) and VEGF receptor-3 (VEGFR-3) in non-small cell lung cancer (NSCLC), and to explore its relationship with lymph node metastasis. Methods Sixty patients with NSCLC were studied. The expression of VEGF-C and VEGFR-3 was detected by immunohistochemistry in lung cancer samples, and its relationship to clinical and pathological data was analyzed. Results The positive expression rate of VEGF-C in NSCLC tissues was 68.3% (41/60), the expression rate of VEGFR-3 was 53.3% (32/60). The expression of VEGF-C was related with the degree of cell differentiation in lung cancer. Both the expressions of VEGF-C and VEGFR-3 were positively associated with lymph node metastasis. There was a positive correlation between VEGF-C and VEGFR-3 expressions (r=0.27). Conclusion The expressions of VEGF-C and VEGFR-3 are related to lymph node metastasis in NSCLC. VEGF-C may promote intratumoral lymphangiogenesis via VEGFR-3 and lymphatic metastasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Cancer Research and Clinic
Ano de publicação:
2010
Tipo de documento:
Artigo
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